ABSTRACT
The development of vaccines from plants has been going on for over two decades now. Vaccine production in plants requires time and a lot of effort. Despite global efforts in plant-made vaccine development, there are still challenges that hinder the realization of the final objective of manufacturing approved and safe products. Despite delays in the commercialization of plant-made vaccines, there are some human vaccines that are in clinical trials. The novel coronavirus (SARS-CoV-2) and its resultant disease, coronavirus disease 2019 (COVID-19), have reminded the global scientific community of the importance of vaccines. Plant-made vaccines could not be more important in tackling such unexpected pandemics as COVID-19. In this review, we explore current progress in the development of vaccines manufactured in transgenic plants for different human diseases over the past 5 years. However, we first explore the different host species and plant expression systems during recombinant protein production, including their shortcomings and benefits. Lastly, we address the optimization of existing plant-dependent vaccine production protocols that are aimed at improving the recovery and purification of these recombinant proteins.
ABSTRACT
The ongoing COVID-19 pandemic should teach us some lessons at health, environmental and human levels toward more fairness, human cohesion and environmental sustainability. At a health level, the pandemic raises the importance of housing for everyone particularly vulnerable and homeless people to protect them from the disease and against other similar airborne pandemics. Here, I propose to make good use of big data along with 3D construction printers to construct houses and solve some major and pressing housing needs worldwide. Big data can be used to determine how many people do need accommodation and 3D construction printers to build houses accordingly and swiftly. The combination of such facilities- big data and 3D printers- can help solve global housing crises more efficiently than traditional and unguided construction plans, particularly under environmental and major health crises where health and housing are tightly interrelated.